The VenaSeal™ closure system treats symptomatic venous reflux disease in the lower extremity superficial venous system, often the underlying cause of painful varicose veins. This procedure uses an adhesive to close the vein. It is the only non-thermal, non-tumescent, non-sclerosant procedure approved for use in the U.S. that uses an advanced formulated medical adhesive that closes the diseased vein. During the procedure, a trained clinician fills a syringe with the medical adhesive, which is inserted into the VenaSeal™ closure system’s dispensing gun that is attached to a catheter. The catheter is advanced into the diseased vein under ultrasound guidance. The catheter is placed in specific areas along the diseased vein and the clinician conducts a series of trigger pulls to deliver the medical adhesive. Compression is applied to the leg during the procedure. The VenaSeal™ closure system procedure is designed to minimize patient discomfort and reduce recovery time. After the procedure, a small bandage will be placed at the access site. Patients are able to rapidly return to normal activities. Additionally, patients have reported minimal bruising following the VenaSeal™ closure system procedure. This treatment has been shown to be effective in three clinical studies, with demonstrated safety and high closure rates.